Louise of Saxe-Gotha-Altenburg (German: Luise; 9 March 1756 – 1 January 1808) was Duchess of Mecklenburg-Schwerin through her marriage to Grand Duke Frederick Francis I. Louise was the fourth and youngest child of Prince John August of Saxe-Gotha-Altenburg and Countess Louise Reuss of Schleiz.

[1] After the death of her mother in 1773, both she and her older sister Augusta inherited the title of co-Countess of Limpurg-Gaildorf as one of the several heirs of William Henry, Schenk of Limpurg zu Gaildorf (d. 1690 without surviving male issue).

[2] Both sisters retained their portions of the Limpurg-Gaildorf inheritance (1/4 of Amt Gaildorf and 1/16 of the town of Gaildorf) until 1780, when they sold their share to Charles Eugene, Duke of Württemberg.

[2] In Gotha on 1 June 1775,[1] Louise married Frederick Francis, Hereditary Duke of Mecklenburg-Schwerin, eldest child and only son of Duke Ludwig of Mecklenburg-Schwerin and his wife Princess Charlotte Sophie of Saxe-Coburg-Saalfeld.

They had six children:[1]