Louise was the youngest daughter of Duke Frederick of Saxe-Hildburghausen and his wife, Duchess Charlotte Georgine of Mecklenburg-Strelitz.

[1] Louise and her sister Therese were both considered very beautiful, and were the subject of the poem “Mit drei Moosrosen,” written by Friedrich Rückert.

[1] To honour the occasion of their marriage, the Civil Guard of Weilberg, including Samuel Luja, composed the "Cantate am Feste der Heimführung des Erbprinzen Wilhelm von Nassau mit der Prinzessin Louise von Sachsen-Hildburghausen."

The marriage was an unhappy one: Louise's husband was not only autocratic in politics, but he was also rude to his family circle and pestered his wife and children.

Following her death, Louise's husband married her sister Charlotte's daughter Princess Pauline of Württemberg.