Princess Maria Carolina Ferdinanda of Bourbon-Two Sicilies[citation needed] (29 November 1820 – 14 January 1861) was a princess of the House of Bourbon-Two Sicilies and an infanta of Spain through her marriage to Infante Carlos, Count of Montemolin, Carlist claimant to the throne of Spain under the name Carlos VI.

[citation needed] Maria Carolina married her first cousin Infante Carlos of Spain, Count of Montemolin, eldest son of Infante Carlos, Count of Molina and his wife Infanta Maria Francisca of Portugal, on 10 July 1850 at Caserta Palace in Caserta, Two Sicilies.

[citation needed] Maria Carolina and her husband died of typhus within a few hours of one another on 14 January 1861 in Trieste.

Maria Carolina had contracted the disease from nursing her husband.

[citation needed] Maria Carolina and Carlos were buried at the Cathedral of St. Just in Trieste.