This landslide-prone and heavily congested highway passes through five districts: Kathmandu, Dhading, Chitwan, Tanahu and Kaski.

The hills that flank the 206 km (128 mi) stretch of the Prithvi Highway from Kathmandu to Pokhara contain some of the most important religious sites in Nepal.

[2] A 25 km (16 mi) road off the main highway connecting Pokhara and Kathmandu links to the historical town of Gorkha.

Apart from these historic points of interest, the highway is lined with modern townships that have sprung up around important road junctions and river crossings.

The 370-metre (1,210 ft) bridge over the Madi River at Damauli may collapse due to a weakened foundation, as it was constructed at the same time as the highway with Chinese assistance.

Sand and rock extraction nearby have weakened the pillars on a crucial bridge of Nepal's busiest highway.

The Krishna Bhir (Nepali: कृष्ण भीर) is a cliff located in Dhading District by the side of Prithivi Highway, approximately 83 km from Kathmandu Valley.

The highway is a two-lane single carriageway road with at-grade intersections, sealed with Double Bituminous Surface Treatment in almost all areas except where regular maintenance is done with asphalt.

Speed limits aren't applied on most of the section, except some warning signs near urban and town areas and a few sharp bends.