The Prix de Guiche is a Group 3 flat horse race in France open to three-year-old thoroughbred colts.
It is run over a distance of 1,800 m (1.1 mi; 8.9 furlongs) at Chantilly in May.
The event is named after Antoine IX (1789–1855), the Duc de Guiche (and later Duc de Gramont), who founded the successful Haras de Meudon stud farm.
The Prix de Guiche was established in 1865, and it was originally held at Longchamp.
The race was abandoned throughout World War I, with no running from 1915 to 1918.