In the early twentieth century, football made its appearance in the Milanese hinterland, parallel to the birth of large heavy industry.

At the helm of the newborn association is placed Iginio Trasi who in addition to the function of president also carries out the role of coach, teaching the principles of this sport to young people recruited in the streets of the city.

Financial problems pushed managers to save on game uniforms: to insert the light blue on the white shirts, the players were forced to sew a horizontal band of fabric.

In the 1946/47 season, under the guidance of coach Eraldo Monzeglio, the team finished in the eleventh place, obtaining a prestigious success against Como and winning all the Milanese derbies within the friendly walls, except for the match against Seregno (Lombardy), lost 1-0.

The 1948/49 season was their best ever in Serie B; at the end of an over the top championship, the Biancocelesti finished in seventh position, behind Legnano, Spal, Alessandria and Hellas Verona; it was an exceptional result for the bigger blazon of the opponents.

The Peduzzi, Pasini and Fontana era began in 1985, a presidential triad that with the coach Alfredo Spada, in 1987, won promotion to Serie C2 and Pro Sesto returned to the professionals.

In the following tournament, however, after a good start, it ends up in the play-outs and, losing them, he immediately returns to C2; the president Luca Pasini thinks not to enroll the team, fortunately the entry of the municipality of Sesto San Giovanni within the association allows the continuation of the adventure.

Pasini therefore prepares the documents for the repechage in the third series; strong of the first place in the merit rankings, Pro Sesto therefore remains in C1.

The club was refounded in 2010 as Associazione Sportiva Dilettantistica Nuova Pro Sesto coming immediately promoted from Promozione Lombardy/C to Eccellenza Lombardy.