[2][3] The magazine debuted on November 6, 1976, during the term of President Luis Echeverría Álvarez, after political pressure caused Scherer to be expelled from his position of editor of Excélsior.

[4][5] Artists and intellectuals donated paintings, ceramics, sculptures and photographs to be auctioned to finance Comunicación e Información, S.A. (CISA), the magazine's publishing company.

Then Gastón García Cantú, a columnist, left the publication because of an article published in Proceso questioning his appointment as director of the National Institute of Anthropology and History.

[citation needed] On November 27, 2005, Proceso published an article titled Amistades peligrosas ("Dangerous friendships"), wherein Raquenel Villanueva, a lawyer who has defended drug kingpins, declares she met Fernando Bribiesca Sahagún, son of Marta, in 2003 with Jaime Valdez Martinez, a client of hers.

The Procuraduría General de la República considers Valdez one of the representatives of drug cartel leader Joaquín "El Chapo" Guzmán Loera.