The oldest records of Romanians in this place are from around 1750, when a few monks, under the guidance of a hieromonk Macarie, lived there in seclusion near the chapel of St. John the Baptist (which gave its name to the skete).

As the number of Romanian monks increased around him, Iustin thought of broadening their cell by making it into a skete, and made a request to the Great Lavra, who agreed and gave its blessing.

In 1820, they received a document of 13 articles, stating that a cell would be recognized "to the devout tribe of Moldavians for creating a coenobitic skiti".

The building of the skete's church began in 1857 and ended 1866 when, on 21 May, on Saints Constantine and Helena feast day, it was sanctified.

On the southern wall of the porch there is a depiction of Mount Athos with the monasteries and the saints living there, between which there are 14 of Romanian origin.

In 1889, the Great Lavra signed a new deed to Prodromos Skete, strengthened by the seal of the Ecumenical Patriarch Dionysius V of Constantinople.

Over the years the skete was enlarged, but the communist regime in Romania confiscated its properties in the country, leaving it without means of living.

This status slowly began to improve after 1963 when the Mount Athos millennium celebration occurred, attended by all heads of the Eastern Orthodox Churches.

The skete started receiving support from the country, and new monks arrived in 1976, founding a community of 10 elders, many of whom were ill.

The money is to be used for restoring and maintaining the four churches and chapels, for promotional materials and for sustaining the activity of the monks.

The Icon of Theotokos "Acheiropoieta" (i.e. not made by human hands) (Romanian: Maica Domnului «Prodromiţa») is the most well-known of the skete.

The skete's library has over 5000 volumes and about 200 manuscripts of which The History of Athonite Monasteries, written by anchorite monk Irinarh Şişman (1845–1920) a century ago, consisting of 10 volumes, with beautiful ornaments, depicts the history of the Holy Mountain, all its monasteries, and the Romanian establishments in them.