While the main series Power Pros focuses on fast-paced but deep gameplay, the gameplay of Professional Baseball Spirits has a focus for realistic graphics and physics, similar to the Pro Evolution Soccer series.

Just like Power Pros, most games in the series are developed under license from the Nippon Professional Baseball (NPB) and the Japan Professional Baseball Players Association (JPBPA), letting them use the league's team names, stadiums, colors, and players' names and likenesses.

On the PlayStation 3 version of Pro Yakyū Spirits 5, the game saw many small improvements.

The game also has more of a television-style presentation, new animations for slap hits, and a new meter that tells players what pitch the CPU batter is expecting.

Professional Baseball Spirits 2011 (プロ野球スピリッツ2011, Pro Yakyū Spirits 2011) is a baseball simulation video game developed by Konami and PawaPuro Productions for the PlayStation 3, PlayStation Portable and Nintendo 3DS that was released on April 14, 2011.

The previous version was released on the 3DS, but publishers have decided to give preference to PlayStation Vita.

Professional Baseball Spirits 2015 (プロ野球スピリッツ2015, Pro Yakyū Spirits 2015) is a baseball simulation video game developed by Konami and PawaPuro Productions for the PlayStation 3 and PlayStation Vita that was released on March 26, 2015.

[13] Konami collaborated with the snack company Callbee to sell baseball card collectibles based on the game, which was sold for a limited time in January 2025.

[14][15] Professional Baseball Spirits 2019 (プロ野球スピリッツ2019, Pro Yakyū Spirits 2019) is a baseball simulation video game developed by Konami and PawaPuro Productions for the PlayStation 4 and PlayStation Vita that was released on July 18, 2019. eBaseball Professional Baseball Spirits 2021: Grand Slam (eBaseball プロ野球スピリッツ2021, eBaseball Pro Yakyū Spirits 2021) is a baseball simulation video game developed by Konami and PawaPuro Productions for the Nintendo Switch that was released on July 8, 2021.

Professional Baseball Spirits 2024 - 2025 (プロ野球スピリッツ2024 - 2025, Pro Yakyū Spirits 2024 - 2025) is a baseball simulation video game developed by Konami and PawaPuro Productions for the PlayStation 5 and Microsoft Windows that was released on September 19, 2024.

The gameplay is largely based of Professional Baseball Spirits A, where the players need to collect virtual cards and bulid own team in various modes.