Ten minutes after liftoff, the Soyuz-U Rocket carrying Progress M-15M successfully delivered the spacecraft to orbit to begin its International Space Station (ISS) Resupply Mission.

Five Maneuvers were conducted to refine the orbit of Progress M-15M before rendezvous operations started early on 22 April 2012.

Kurs is the system used by Progress spacecraft for automated rendezvous and docking with the space station.

On 22 July 2012, Progress M-15M undocked from the Pirs Docking Compartment and tried to perform a re-rendezvous two days later to test the new Kurs-NA navigation antenna.

Two orbits after the abort, Russian flight controllers commanded the automated rendezvous system to re-activate for the collection of data.

When Kurs-NA was successfully activated at 23:00 UTC on 28 July 2012, it locked on to the passive Kurs-P on the Zvezda service module of the ISS.

The re-rendezvous, fly-around and docking to the space station's Pirs compartment successfully occurred at around 01:00 UTC on 29 July 2012.

Among the cargo items inside the Progress, there was a special present for the Russian cosmonaut Gennady Padalka, who arrived at the ISS on 15 May 2012 and is expected to celebrate his 54th birthday in orbit on 21 June 2012.