[1] Progress M-53 was launched by a Soyuz-U carrier rocket from Site 1/5 at the Baikonur Cosmodrome.

[1] The spacecraft docked with the aft port of the Zvezda module at 00:41:31 UTC on 19 June 2005.

[2][3] The docking was conducted using the backup TORU system, under the control of cosmonaut Sergei Krikalev, due to a power failure at one of the spacecraft's ground control stations.

[4] It remained docked for 80 days before undocking at 10:25:57 UTC on 7 September 2005[2] to make way for Progress M-54.

[2][5] Progress M-53 carried supplies to the International Space Station, including food, water and oxygen for the crew and equipment for conducting scientific research.