A Soyuz-2.1b launched Progress M-UM to the International Space Station from Baikonur Site 31/6 on 24 November 2021, at 13:06:40 UTC for delivery of the Prichal module.

[1][2][4] Due to the larger diameter of the Prichal module, the Progress M-UM was launched in a 4.1 m (13 ft) wide ST-type fairing.

The ISS flight manifest drafted by Roscosmos at the end of summer 2020 set the launch of the Prichal module for 6 September 2021, with the docking to Nauka's nadir port two days later.

The propulsion section then undocked, revealing Prichal's nadir docking port for future Russian spacecraft.

The propulsion section re-entered the atmosphere of Earth for destruction over the South Pacific Ocean, on 23 December 2021, at 04:30:54.