In June 2018, the launch was scheduled for 31 October 2018, but in the wake of the Soyuz MS-10 accident it had to be postponed on 16 November 2018.

[4] Progress MS-10 launched atop a Soyuz-FG rocket on 16 November 2018, at 18:14:08 UTC [5] from the Baikonur Cosmodrome in Kazakhstan.

[6] Progress MS-10 docked as scheduled with the aft docking port of the Zvezda module on 18 November 2018 at 19:31:38 UTC.

[7] The Progress MS-10 spacecraft delivered 2,564 kg of cargo and supplies to the International Space Station.

The following is a breakdown of cargo bound for the ISS:[2][4] It undocked at 08:40 UTC and deorbited in Pacific Ocean, on 4 June 2019 at 11:28 UTC.