After a nominal two-day free flight, it docked with the zenith (space facing) port of the ISS's Poisk module on 23 November at 14:31:16 UTC.

[5] However, some within the Russian space industry believe that the smell and droplets are likely related to the departure of the previous Progress MS-27 cargo ship on 19 November 2024.

As a result, highly toxic hypergolic propellants could have remained in the lines and spilled onto the docking mechanism as Progress MS-27 undocked.

When Progress MS-29 arrived, the remaining propellant on the docking mechanism was trapped inside the hatch, allowing it to enter the station when it was opened.

In its unpressurized section, the spacecraft carries tanks of water, fuel, and gases to replenish the station’s resources and sustain its onboard atmosphere.