The authors also reported that the use of systemic isotretinoin resulted in almost complete resolution of the lesions in two cases.
[4][5] Skin plaques start to appear as reddened areas of inflammation, thus often leading to the mistaken diagnosis of Atopic Dermatitis.
Following inflammation, the red areas start keratinization, eventually forming the definitive plaques that appear brownish, dry and scaled.
[citation needed] Though environmental causes are not well understood, it seems clear that factors like sun exposure, wind and air conditioning add to the degree of skin inflammation that sets the start of a new cycle.
[citation needed] This includes erythrokeratodermia variabilis and loricrin keratoderma Definitive treatment does not exist at the moment.