"[8] The theme of Heresy was the continuation of the War in Heaven between angels and demons in a futuristic cyberpunk setting.

Each type of card is associated with one of eight convictions: Acquisition, Devotion, Evolution, Preservation, Rebellion, Stagnation, Technology, and Tradition.

[1][10] There are six types of cards:[1] A player wins once he or she has generated enough tau to open a portal with which to ascend to Heaven.

The larger card size showcased art by such well-known artists as Tim Bradstreet, Gerald Brom, Michael W. Kaluta, Tom Kidd, James O'Barr, Andrew Robinson, Barclay Shaw, John K. Snyder III, Karl Waller, and Bernie Wrightson.

[12] Faragher comments that "Heresy is a wonderful game that proves that startlingly original atmosphere is just as important as innovative mechanics in CCG.