As a bishop of Iconium, modern Konya, in central Anatolia, he was involved with the issue of the creation of the Turkish Orthodox Church.

In 1899 he became Metropolitan of Dyrrachium (modern Durrës in central Albania), where he developed significant activity among the local Orthodox communities.

In 1906 he was installed in the Anatolian city of Philadelphia (Alaşehir, Asia Minor), as the head of the local bishopric.

[2] In September 20, 1920, as a result of his intervention, Prokopios, as well as the local Armenian bishop of Konya, were imprisoned by the nationalist authorities of Mustafa Kemal.

Soon after his release, he visited Ankara, where he met Mustafa Kemal in an attempt to ask him to abstain from the ecclesiastical dispute concerning the creation of the Turkish Orthodox Patriarchate, due to severe health problems he suffered.