Prometeo in its final form (1985) is scored for:[1] The work's nine sections are:[1] At the premiere of the first version, at the Church of San Lorenzo in Venice on 25 September 1984, Claudio Abbado was the conductor, with the Chamber Orchestra of Europe, a choir from the Hochschule für Musik Freiburg, and the following vocal soloists:[1][2] Ingrid Ade, Monika Bair-Ivenz, Bernadette Manca di Nissa, Susanne Otto, and Mario Bolognesi.

The revised and final Prometeo premiered at Teatro alla Scala in Milan on 25 September 1985, conducted by Peter Hirsch.

The performances at Festival d'Automne in Paris and Alte Oper Frankfurt featured Ensemble Modern and conductors Friedrich Goldmann and David Shallon.

[4] A March 1997 production by Robert Wilson in Brussels (Festival Ars Musica / La Monnaie) was conducted by Péter Eötvös and Kwamé Ryan.

[5] The work was later also presented as part of the Berliner Festspiele in September 2011 under Matilda Hofman (Conductor II) and Arturo Tamayo (Conductor I); Cyndia Sieden, Silke Evers, Susanne Otto, Noa Frenkel, and Hubert Mayer were the vocal soloists, with the Konzerthausorchester Berlin.