[1] Biden reflects on losing his eldest son Beau to brain cancer and the toll it took on him and his family.

"[2] Biden also talks about the political implications his son's death had: his decision not to run for president in 2016 was in large part due to the grief he was still processing.

[3] He was further discouraged from running by Hillary Clinton's entry into the race and President Obama's implied preference that Biden not dilute her support in the primary elections.

[2] The title of the book was inspired by a conversation Biden had with Beau after his cancer had progressed significantly.

[4] Vanity Fair called the book "a brisk, often uplifting read, a consequence of its author’s congenital jollity and irrepressible candor.