Elements of this fresco have inspired various artists, including Caravaggio and Norman Rockwell in his famous Rosie the Riveter illustration.

[1] This particular fresco figure is painted fourth on the right from the side of the High Altar.

Michelangelo's imagining bursts with movement, as Isaiah's cloak swirls around him.

Vasari said of it: "Anyone who studies this figure, copied so faithfully from nature, the true mother of the art of painting, will find a beautifully composed work capable of teaching in full measure all the precepts to be followed by a good painter".

[2] If compared to Raphael's imagining of the same figure, Michelangelo's portrayal seems far more fluid and less muscular, as well as brighter in color.