N-n-Propylnorapomorphine (NPA) is an aporphine derivative dopamine agonist closely related to apomorphine.

[2][3] In rodents it has been shown to produce hyperactivity, stereotypy, hypothermia, antinociception, and penile erection, among other effects.

[4][5][6][7] Notably, its effects on locomotion are biphasic, with low doses producing inhibition and catalepsy and high doses resulting in enhancement of activity.

[8] This is likely due to preferential activation of D2/D3 autoreceptors versus postsynaptic receptors,[9] the latter of which overcomes the former to increase postsynaptic dopaminergic signaling only with high doses.

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