Among those buried in the cemetery are politician Christian Herter, who served as U.S. Secretary of State and Governor of Massachusetts, and two Medal of Honor recipients, Charles Church Roberts and William D. Newland.

The cemetery was listed on the National Register of Historic Places in 2006 with the help of a short documentary film by a Millis High School Freshman Dustin Fresh.

The outer boundaries retain a wooded character, while some slopes on the interior have been terraced to increase burial space.

The very oldest portion, with burials dating to 1714, is at the top of Prospect Hill, where the site of the first meeting house in Millis is also located, marked by a series of original granite stone steps and a commemorative boulder.

This area features winding lanes and mature tree plantings, and is set partly in a horseshoe-shaped bowl, giving a fine vista over the terrain.