Prospero Pubblicola Santacroce (24 September 1514 – 2 October 1589) was an Italian Roman Catholic bishop and cardinal.
The next year he was an auditor of Cardinal Alessandro Farnese, who was then papal legate a latere in the Holy Roman Empire.
[1] He did not, however, participate in the papal conclave of 1565-66 that elected Pope Pius V.[1] He received the red hat and the titular church of Saint Jerome of the Croats on February 8, 1566.
He opted for the titular church of Santa Maria degli Angeli e dei Martiri on April 12, 1570.
[1] On May 5, 1574, he opted for the titular church of Sant'Adriano al Foro (a deaconry raised to the status of title pro illa vice).
[1] He was a participant in the papal conclave of 1585 that elected Pope Sixtus V.[1] On March 2, 1589, he opted for the order of cardinal bishops, receiving the suburbicarian see of Albano.