In the novel Moby-Dick, as well as various productions based on the novel, Captain Ahab is a man who loses one of his legs to the great sperm whale Moby Dick.
Mister Ming, the main antagonist of the Bob Morane books, has a robotic prosthesis instead of his right hand, which was lost during an attempt to steal a booby trapped gemstone.
The television series The Six Million Dollar Man and its spinoff The Bionic Woman both featured main characters whose replacement parts gave them abilities above those of normal people.
In the Harry Potter novel series, Alastor "Mad-Eye" Moody has an artificial eye (able to see through solids) and a wooden leg to compensate for wounds he received during his career as an Auror.
Because Rotwang is an early "mad scientist" archetype, it is believed that this influenced other characters, such as Dr. Julius No (who, in the novel, had jointed metal claws; in the movie, however, he possessed actual artificial hands).
In the Akira manga and anime Tetsuo Shima, one of the main characters, loses his right arm and it is replaced by a mechanical limb.
and its sequel is Lloyd Bridges's character, Thomas 'Tug' Bensen, featuring various prosthetics that replace parts he had lost in earlier battles.
These prosthetics include ceramic eyes, asbestos skin, a magnetic skull plate, aluminum siding facial bones, and stainless steel ear canals.
In the novel The Horse Whisperer (and the film of the same name), Grace MacLean loses part of her right leg when she is involved in a horseback riding accident and struck by a truck.
The character Peeta Mellark from The Hunger Games loses his left leg at the end of the novel, after surviving a bad wound and blood poisoning.
In Metal Gear Solid V: The Phantom Pain the video game main character Punished "Venom" Snake is outfitted with a prosthetic Bionic Arm after a helicopter crash.
In the web series RWBY, Yang Xiao Long is enraged at the sight of Adam Taurus stabbing her partner Blake Belladonna in the torso, so she attempts to punch him.
It appears to be extremely powerful, able to withstand Black Widow's electric taser darts with little effect, and makes him almost capable of outmatching Captain America.
In the young adult realistic fiction novel The Running Dream, the protagonist Jessica is a runner who loses a leg in a bus accident on her way home from a race.
In the Jojo's Bizarre Adventure manga and anime, the series' second titular character, Joseph Joestar, loses his left arm below the elbow in his final fight at the end of Part 2, at age 18.