Protitanotherium is a genus of brontotheres native to North America during the middle Eocene.

It contains one species, P. emarginatum, described in 1895 by the American paleontologist John Bell Hatcher.

[1] In 1895, John Bell Hatcher described a partial cranial material from the Uinta Formation of Utah, YPM-PU 11242, as the holotype of a new species of brontothere.

He tentatively included the taxon as a species of Diplacodon (D. emarginatum), but he noted that "should future discoveries show that there are hornless forms with same dental characters as Diplacodon", it would require a new genus name Protitanotherium.

[1][5] Fragmentary brontothere specimens from the middle to late Eocene strata of North Korea were named as P. koreanicum by Takai (1939), but this species is now considered as a nomen dubium.