The hotel opened to much fanfare on June 6, 1922,[4] and was the second-tallest building in the city after the Rhode Island State House, until the Industrial Trust Tower was finished six years later.

The hotel was the backdrop for many Rhode Island political and social scandals over the years, many of which are documented in the book Meet Me At The Biltmore.

In 1975, amidst a flurry of lawsuits over tens of thousands of dollars of unpaid utility bills and back taxes, Gotham Hotels was forced to close the Biltmore.

[9] A group of local businessmen, including Bruce Sundlun of the Outlet Company, Michael Metcalf of The Providence Journal, G. William Miller of Textron, and Jim Winoker and Dominic Zinni of B.B.

[10] The Biltmore's external glass elevator was added during this renovation, and served all 18 floors of the hotel (though it no longer runs).

[14] Finard Coventry invested a further $10 million in renovations,[15] and the hotel joined Curio, A Collection by Hilton, on December 16, 2014.

[16] In October 2017, the Biltmore was sold to AJ Capital Partners, a Chicago-based hotel and real estate firm, for $43.6 million.

The rooftop level Grand Ballroom offers expansive views of the city and Kennedy Plaza and can hold up to 750 guests; its event space is designed for functions such as wedding receptions, banquet service, and conferences.

In 2022, author Amanda Quay Blount published Meet Me At The Biltmore,[21] a book chronicling the hotel's storied past alongside Providence's highs and lows throughout the 20th century.