Province of Santa Cruz de Tenerife, also Province of Santa Cruz (Spanish: Provincia de Santa Cruz de Tenerife), is a province of Spain, consisting of the western part of the autonomous community of the Canary Islands.

It also includes a series of adjacent roques (those of Salmor, Fasnia, Bonanza, Garachico and Anaga).

Earlier issued vehicle license plates in this province bear the first two letters "TF" (named after Tenerife).

Nowadays the plates share the same numbering system as in mainland Spain.

In 1982, both provinces became part of the newly founded autonomous community of the Canary Islands.