The fifth season of Psych, consisting of 16 episodes, premiered on USA Network in the United States on July 14, 2010 and concluded on December 22, 2010.

James Roday, Dulé Hill, Timothy Omundson, Maggie Lawson, Corbin Bernsen and Kirsten Nelson all reprised their roles as the main characters.

For "Shawn 2.0", guest star Curt Smith recorded an interpretation of the theme, and Julee Cruise performed a slower extended version for "Dual Spires".

John Badham, Andrew Bernstein, Jay Chandrasekhar, Tawnia McKiernan, James Roday, Matt Shakman, and Stephen Surjik directed one episode each.

Timothy Omundson returned as Head Detective Carlton "Lassie" Lassiter, while Maggie Lawson continued to portray Juliet "Jules" O'Hara.

Other notable guest stars for the season included Kevin Alejandro, Dana Ashbrook, Doron Bell Jr., April Bowlby, Catherine E. Coulson, Tony Cox, John DeSantis, William Devane, Nora Dunn, Sherilyn Fenn, Lee Garlington, Jon Gries, Michael Gross, Danielle Harris, John Michael Higgins, C. Thomas Howell, Brian Klugman, Rob LaBelle, Don Lake, Sheryl Lee, Robyn Lively, Bruce Locke, Ralph Macchio, Angus Macfadyen, April Matson, Chi McBride, Ryan McDonald, Vanessa Minnillo, Meredith Monroe, Becky O'Donohue, Franka Potente, Freddie Prinze, Jr., Keshia Knight Pulliam, Brad Raider, Adam Reid, Adam Rodriguez, Jean Smart, Charles Martin Smith, Curt Smith, Lauren Lee Smith, Mena Suvari, Jacob Vargas, Lenny Von Dohlen, and Carl Weathers.