It is found on the East African Plateau in Rwanda, Burundi, and Tanzania in the north and then southward to eastern Democratic Republic of the Congo, northern Angola, Zambia, Malawi, Zimbabwe and uplands of Mozambique.

There are light dorsolateral skin folds running along each side of the body.

The back of the thigh is faintly spotted, but may in some individuals join to form a horizontal band.

[4] Ptychadena uzungwensis lives in medium- to high-altitude grasslands (800–2,300 m (2,600–7,500 ft) above sea level) near pools, seepages, dambos and permanent sponges, its presumed breeding habitat.

It occurs in a number protected areas, including the Upemba National Park in the southeastern Democratic Republic of Congo.