Public Health Act of 1879 or National Board of Health Act, 1879 was a United States federal statute authorizing the creation of the National Board of Health.

The Act of Congress was an appeal for a national public health organization and national quarantine system for purposes of contagious or infectious diseases discovered in nineteenth century America.

The United States public law sanctioned the newly formed National Health Board and Academy of Sciences to provide reports concerning public health information with regards to the Perpetual Union or States for the purposes of; The forty-fifth United States Congress authored the public law as four sections sanctioning the needs for conformity concerning public health incidences, uniformity of incident reports, and a national public health organization.

The 50th United States Congress passed legislation to enhance and improve the quarantine service for nineteenth century America.

In 1888, public laws were enacted by the 22nd President of the United States Grover Cleveland which established eight quarantine stations for the United States coast to coast territorial waters.