Rio Piedras Pueblo is bounded to the west by Hato Rey Sur and El Cinco, with Universidad barrio to the North, and with Sabana Llana Sur barrio to the south and east.

It is made up of 6 subbarrios: Buen Consejo, Capetillo, Monte Rey, Río Piedras Antiguo, Ubarri, and Venezuela.

The University of Puerto Rico, Rio Piedras is located nearby.

Before the establishment of the town square, the area was the site of the Hermitage of Our Lady of the Pillar since at least 1647.

The old city house and Casa del Rey date to this time.