It first reached the national competitions in 1955, playing in Tercera División and achieving immediate promotion after finishing fourth.

During the club's first season in Segunda División, it changed its name to Puente Genil CF.

After suffering immediate relegation, the club also dropped a division in 1960 and folded in 1973.

Puente Genil FC started to play in the regional leagues in 2000, and in 2010 the club changed its name to CD AD San Fermín.

In 2018 the name was changed to Salerm Cosmetics Puente Genil FC mainly due to its previous history.