Puerto Aysén is a city of Chile located in the Aysén del General Carlos Ibáñez del Campo Region, 4 kilometres (2 mi) above the head of Aisén Fjord in the country's extreme south.

Puerto Aisén, which is the capital city of both the Aysén Province and the commune of Aisén is located 65 kilometres (40 mi) from the Regional Capital of Coyhaique, and 15 kilometres (9 mi) from the port of Puerto Chacabuco, main entry point to Puerto Aisén by sea.

The main tourist attraction is Lagoon San Rafael.

The port of Chacabuco serves passenger ferries but also cargo traffic: fuel and other necessities are imported while live cattle and other agricultural produce are exported.

Typical of oceanic climates, precipitation peaks in late fall and early winter.