In June 2015, National Basketball Association (NBA) star Carmelo Anthony announced that he is bringing football back to Puerto Rico with a new North American Soccer League expansion franchise.

[3] On August 14, 2015, Adrian Whitbread was announced as the club's inaugural coach,[4] with Thomas Payne being appointed as president on November 10, 2015.

[5][6] Puerto Rico FC made their home debut on July 2, 2016, at Juan Ramón Loubriel Stadium, drawing 1–1 to Indy Eleven, in front of a crowd of 6,474.

On January 26, CONCACAF announced PRFC would host group D in the 2017 CFU Club Championship at Juan Ramón Loubriel Stadium starting March 14.

Shortly before the start of third match, Puerto Rico was eliminated from the tournament due to Portmore United finishing the group stage with three wins from games.

PRFC played well defeating Scholars International SC of the Cayman Islands 4–0; with goals coming from debuted Mike Ramos, Sidney Rivera, Brian Bement, Cristiano Dias.

[13] Puerto Rico FC played their home matches at the renovated Juan Ramón Loubriel Stadium located in Bayamón.

On June 29, 2016, Puerto Rico FC signed an exclusive deal with local television channel WAPA TV.