Puerto Rico Highway 129 (PR-129) is a north–south (actually diagonal) highway in North-Central Puerto Rico, connecting the town of Lares with Arecibo.

When traveling from the northern coast of Puerto Rico, PR-129 can be used to reach the Arecibo Observatory and the Camuy River Caverns Park.

It then heads south as a narrow, rural road, and ends at PR-135 near Adjuntas.

Its speed limit is overall 45 miles per hour (72 km/h) through its highway section.

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