The road is frequently congested, in particular during rush hour due to heavy commuter traffic.

The following is the list of municipalities/towns which PR-22 cuts through, in order from San Juan to Hatillo (westbound): In 2013, the Puerto Rico Highways and Transportation Authority and Metropistas inaugurated express lanes with dynamic tolling (DTL) between Bayamón and Toa Baja to help alleviate traffic congestion during peak hours.

These reversible lanes extends from Río Hondo to the Toa Baja Toll Plaza with a variable rate between $1.75 and $4.95 per direction.

[8] In 2011, the Autopistas Metropolitanas de Puerto Rico (Metropistas) consortium, comprised by Abertis Infraestructuras and Goldman Sachs Infrastructure Partners II LP, placed the winning bid for the 40-year PR-22 and PR-5 highway concession.

[citation needed] PR-22 is maintained by a system of tolls managed by the Puerto Rico Department of Transportation and Public Works.

The future segment from Hatillo to Aguadilla is expected to have four additional toll plazas;[13] however, it remains to be seen whether they will be one way or two way.