With a length of 30.1 km (18.7 mi), it begins at its intersection with PR-5155 in downtown Orocovis and ends at PR-159 in western Corozal.

[4] In Corozal, PR-568 continues to the north on its way through Magueyes, Palmarito, Negros, Cuchillas and Padilla barrios until its end at PR-159 on the Padilla–Cibuco line.

10, a highway that led from Dorado to Coamo through Toa Alta, Corozal and Orocovis until the 1953 Puerto Rico highway renumbering, a process implemented by the Puerto Rico Department of Transportation and Public Works (Spanish: Departamento de Transportación y Obras Públicas) that increased the insular highway network to connect existing routes with different locations around Puerto Rico.

[13] Puerto Rico Highway 5568 (PR-5568) is a spur route located in Padilla, a barrio of the municipality of Corozal.

PR-5568 is a rural road with one lane in each direction along its entire length and serves as access to several neighborhood in western Padilla.