The Puisaye (French pronunciation: [pɥizɛ] ⓘ) is a natural and historical region of France, now divided between the departments of Loiret, Nièvre and Yonne.

It is bordered by Sancerrois to the west across the Loire river, Gâtinais to the northwest, Auxerrois to the northeast, Forterre to the southeast, and Donziais to the south.

A Carolingian manuscript lists several Puisaye parishes on the itinerary of Saint Aunarius, Bishop of Auxerre in the late 6th century, namely Neuvy-sur-Loire (Novus Vicus), Briare (Brioderus), Bléneau (Blanoilus), Bitry (Vitriacus), and Arquian (Arcuncius), and also refers to Toucy (Tociacus).

[3][4] The lordship of Toucy was prominent in the High Middle Ages, as several of its leaders and family affiliates played significant roles, not least as associates of the House of Courtenay in their overseas endeavors.

The crisis of the late Middle Ages and specifically the Hundred Years' War marked a rupture in the history of the region.

Toucy was devastated in the runup to the Battle of Cravant, and was subsequently displaced by Saint-Fargeau as the main urban center of the Puisaye.

Generally, the century between 1450 and 1550 was a time of prosperity and renewal in the region, still represented in the landscape by numerous village churches built during that era.

By the end of France's Ancien Régime, the core of Puisaye including Bléneau, Saint-Fargeau, Toucy and Saint-Sauveur was part of the province of Orléanais.

The lordship of Puisaye was inherited by the Counts, then Dukes of Bar following the 1255 marriage between Theobald II, Count of Bar and Joanna of Toucy, heiress of a lineage that started with Ythier de Narbonne in the 11th century (Maison de Toucy [fr]).

These domains later went to François, Duke of Montpensier following his 1566 marriage with Renée d'Anjou-Mézière [fr], daughter of Nicolas d'Anjou.