Puisseguin (French pronunciation: [pɥis(ə)ɡɛ̃]; Occitan: Puègseguin) is a commune in the Gironde department in Nouvelle-Aquitaine in southwestern France.

In October 2015, 43 people died in a crash between a bus and a lorry.

[3] Located in the Pays du Libournais.

The neighboring towns are Lussac in the north, Tayac in the extreme north-east for about 250 meters, Saint-Cibard to the East, Saint-Philippe-d'Aiguille at the South-East, Saint-Genès-de-Castillon at the South and Montagne in the west.

This Gironde geographical article is a stub.