Puka Mayu (Quechua puka red, mayu river,[1] "red river") is a Bolivian river in the Potosí Department, Nor Lípez Province, Colcha "K" Municipality.

[2][3] It originates in the Cordillera de Lípez[4] and empties into the Uyuni salt flat.

The mouth lies west and south west of the town Uyuni and north east of the mouth of the Río Grande de Lípez.

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