Puksoozero (Russian: Пуксоозеро) is a rural locality (a settlement) in Plesetsky District of Arkhangelsk Oblast, Russia, located 22.2 kilometers (13.8 mi) southeast of Plesetsk, on Lake Puksoozero, at the source of the Puksa River, the left tributary of the Mekhrenga.

The main occupation of the population was timber production and construction of the railroad connecting Puksoozero and Puksa railway station.

The construction was mainly carried out by prisoners of "Onegalag", with the headquarters located in the town of Plesetsk.

Three of these were located directly adjacent to the settlement, and the remaining camps were built along the 140-kilometer (87 mi) railway.

Puksoozero had work settlement status until it was demoted to a rural locality in February 2013.

[3] A road connects Puksoozero with the urban-type settlement of Plesetsk; there is regular passenger bus traffic.