Punicalagin (Pyuni-cala-jen) is an ellagitannin, a type of phenolic compound.

It is found as alpha and beta isomers in pomegranates (Punica granatum), Terminalia catappa, Terminalia myriocarpa,[1] and in Combretum molle, the velvet bushwillow, a plant species found in South Africa.

Punicalagins are water-soluble and hydrolyze into smaller phenolic compounds, such as ellagic acid.

There were no toxic effects in rats on a 6% diet of punicalagins for 37 days.

[3] In laboratory research, punicalagins had carbonic anhydrase inhibitor activity.