The series focuses on the titular character Puniru, a slime girl created by a boy named Kotaro Kawaii during his childhood and wants him to notice her for her cuteness despite him being in love with his junior high school senior.

A young boy named Kotaro Kawaii made a slime as part of a science experiment which came to life.

[5] Puniru Is a Cute Slime started its serialization in Weekly CoroCoro Comic online service on March 15, 2022.

[15][16] It is produced by Toho Animation Studio and directed by Yūshi Ibe, with scripts written by Michiko Yokote, Aya Tanaka providing the character designs and Izumi Mori composing the music.

[21] Medialink licensed the series in Asia-Pacific (except Australia and New Zealand) for streaming on Ani-One Asia's YouTube channel.

[28] Along with Burning Kabaddi, Kore Kaite Shine, and Natsume Arata no Kekkon, Puniru Is a Cute Slime won the 70th Shogakukan Manga Award in 2024.