Hampton impressed Funkadelic's George Clinton by performing a note-for-note rendition of Hazel's ten-minute solo "Maggot Brain".
Hampton became a fixture in Funkadelic, and he continued his role as lead guitarist even during Hazel's sporadic returns to the band.
The bonus-EP of Funkadelic's One Nation Under a Groove (1978) included a live version of the song featuring Hampton.
One of his most celebrated performances is the lead guitar solo on the Funkadelic hit single "(Not Just) Knee Deep" from 1979, as well the title track to the Brides of Funkenstein's second album Never Buy Texas From A Cowboy.
In 1981, Clinton was forced to disband the P-Funk musical empire due to financial and legal difficulties.