The airport has mainly been used for general aviation, but has recently seen more scheduled airline service, with flights offered by Allegiant Air to fifty-one destinations.

[10] Provincetown-Boston Airlines (PBA) operated service between PGD and Tampa International Airport in the early 1980s on Douglas DC-3 and Cessna 402 aircraft.

[14] Airline service resumed on November 22, 2008, when low-cost carrier Direct Air began twice weekly service to 10 cities in the eastern U.S. On December 2, 2008, low-cost airline Allegiant Air also announced it would open a new focus city at PGD and began McDonnell Douglas MD-80 flights to Greenville, South Carolina and Knoxville, Tennessee on March 5, 2009.

Vision then offered through ticketing for flights from Punta Gorda to Atlanta, Savannah, and Asheville via connections at the airline's Destin/Fort Walton Beach hub.

Shortly after the collapse of Direct Air, Allegiant grew their PGD presence from three to seven cities and started basing aircraft full-time at the airport.

Frontier Airlines briefly served PGD in late 2016 to mid 2017 offering flights to Philadelphia, Chicago-O'Hare, and Trenton which had been relocated from nearby Southwest Florida International Airport in Fort Myers.

The Florida International Air Show is a 501(c)(4) nonprofit organization operated wholly by several hundred volunteers that include airport staff.

[20] Each year, the Florida International Air Show donates proceeds to various local charities that provide their volunteers for the setup, operations, and breakdown of the event.

[23] In the year ending December 31, 2023 the airport had 103,252 aircraft operations, an average of 283 per day: 85% general aviation, 12% airline, 2% military, and 1% air taxi.