Purisima Creek is a 2-mile-long (3.2 km)[3] eastward-flowing stream originating in Los Altos Hills in Santa Clara County, California, United States.

Gudde's "California Place Names" incorrectly asserted that there was no namesake for the land grant in Santa Clara County.

[5][6] One of the founders of Hewlett-Packard, David Packard, lived on the upper watershed of Purisima Creek on a property with a large apricot orchard.

At the base of the property the two forks come together to form the creek mainstem which levels out as it passes through the remains of an old walnut grove, then crosses Elena Road, flowing along Josefa Lane and the northwestern edge of Foothill College to where it passes under I-280, then along O'Keefe Lane and the O'Keefe Open Space Preserve to its confluence with Adobe Creek just inside Los Altos.

This section of the creek has been invaded by non-native species that compete with the native vegetation for its water, including Canary Island palm (Phoenix canariensis), common fig (Ficus carica), plum (Prunus), blue gum eucalyptus (Eucalyptus globulus), European olive (Olea europaea) and Siberian elm (Ulmus pumila).