Puyehue (Spanish pronunciation: [puˈʝewe]) is a commune in Chile located in Osorno Province of Los Lagos Region.

Cardenal Antonio Samoré Pass that links the Los Lagos Region to Argentina lies in the eastern tip of the commune.

According to the 2002 census of the National Statistics Institute, Puyehue spans an area of 1,597.9 km2 (617 sq mi) and has 11,368 inhabitants (6,008 men and 5,360 women).

[2] As a commune, Puyehue is a third-level administrative division of Chile administered by a municipal council, headed by an alcalde who is directly elected every four years.

The commune is represented in the Senate by Camilo Escalona Medina (PS) and Carlos Kuschel Silva (RN) as part of the 17th senatorial constituency (Los Lagos Region).