The project can also be cross compiled to embedded systems like Raspberry Pi,[3][4] and Android devices.

[5] By 2009, Nokia, the then owners of the Qt toolkit, wanted Python binding available under the LGPL license.

Nokia failed to reach an agreement with Riverbank Computing, the developers of the PyQt Python binding.

[6] There have been three major versions of PySide:[9] PySide version 1 was released in August 2009 under the LGPL by Nokia,[1] then the owner of the Qt toolkit, after it failed to reach an agreement with PyQt developers Riverbank Computing[10] to change its licensing terms to include LGPL as an alternative license.

It later created its own binding generator named Shiboken,[15] to reduce the size of the binaries and the memory footprint.[16][when?]