Pymble is 15 kilometres (9 mi) north of the Sydney central business district in the local government area of Ku-ring-gai Council.

Based on settlers' accounts, the land that came to be known as Pymble was traversed by, and at least periodically inhabited by, the Cammeraigal clan or tribe of the Kuringai (also known as Guringai) Aboriginal people.

The other half (plus a large part of St Ives) was granted to Daniel der Matthew's, another influential settler who established the first sawmill in the area.

It became widely known for the high quality of its produce and especially for its oranges which had been introduced to the area by Robert Pymble sometime around 1828 and which by later years were grown extensively throughout the region by numerous different growers following land sub-divisions.

During the interwar years, Pymble became a desirable residential area for middle-class families, as it was well-connected by rail to the central business district of Sydney, but still offered a semi-rural environment.

Pymble's foundations for the community and infrastructure would continue to grow throughout the 20th century, in characterisations of residential areas, green spaces and local amenities.

The station is the centre of transport, shopping and social activities whilst Pymble Hill affords a view of the distant Chatswood skyline.