Pyrenula muriciliata is a species of corticolous (bark-dwelling) and crustose lichen in the family Pyrenulaceae.

Pyrenula muriciliata it was formally described as a new species in 2020 by Paul Diederich and Damien Ertz.

The type specimen was collected by the first author in the Brise Fer Forest in Black River Gorges National Park (Rivière Noire District) at an altitude of 585 m (1,919 ft); it has also been recorded from two other locations in Maurutius, Pétrin and Curepipe, with a total elevation range between 565–680 m (1,854–2,231 ft).

The specific epithet muriciliata refers to these characteristic spore features.

[1] All chemical spot tests are negative, and no secondary compounds were detected with thin-layer chromatography.